The Regulation (EU) 2024/1938 on substances of human origin (SoHO) represents the most significant transformation in European blood and tissue management in over two decades. Adopted by the European Parliament and Council on June 13, 2024, this regulation establishes unified quality and safety standards for all substances of human origin intended for human application across the European Union. In this short flyer we have summarized the four pillars of SoHO compliance which we aim to achieve together with our partners.