Anemia, red blood cell transfusion and administration of blood products in obstetrics

The study analyzes data from over 6 million pregnant women, finding a significant correlation between anemia and increased maternal morbidity and mortality. Anemia was present in 23.74% of all women studied. Pregnant women who receive RBC transfusions face higher rates of postpartum hemorrhage and complications, including longer hospital stays and increased ICU admissions. The study highlights the potential benefits of implementing Patient Blood Management (PBM) strategies to reduce the need for RBC transfusions and improve maternal health outcomes. The findings underscore the importance of addressing anemia during pregnancy to reduce associated risks and improve overall maternal and fetal health.

Study population

• The study population consisted of 6,356,046 pregnant women who delivered in hospitals in Germany between January 1, 2011, and December 31, 2020
• Per 100,000 women, 799 received red blood cells
• 250 received Fibrinogen
• 47 received platelets
• 44 received prothrombin complex concentrate
• and 23 massive blood transfusions

Conclusions

Future advancements in transfusion medicine, particularly in obstetrics, could significantly reduce the prevalence of anemia and the need for red blood cell transfusions through the effective implementation of Patient Blood Management (PBM) strategies, ultimately improving maternal and fetal health outcomes.

Cite

Kloka JA, Friedrichson B, Jasny T, Old O, Piekarski F, Zacharowski K, Neef V. Anemia, red blood cell transfusion and administration of blood products in obstetrics: a nationwide analysis of more than 6 million cases from 2011-2020. Blood Transfus. 2024 Jan;22(1):37-45. doi: 10.2450/BloodTransfus.528. Epub 2023 Sep 15. PMID: 37847205; PMCID: PMC10812898.