Study Director
Kai Zacharowski is an anaesthesiologist, intensive care physician and clinical pharmacologist. His research focuses on risks in anaesthesia and intensive care medicine, the complex interaction of the immune and coagulation systems, blood poisoning (sepsis) and patient blood management. He is intensively involved with blood poisoning (sepsis), blood supply in intensive care medicine and blood coagulation management. Kai Zacharowski has developed an evidence-based blood management system (Patient Blood Management, PBM) with which blood transfusions can be used more sparingly than before. His research contributes to greater patient safety in hospitals, for which he has been honoured with numerous prestigious awards.
July 2009
University Hospital Frankfurt
October 2016
in Hesse, Germany
November 2016
Germany
December 2016
BJA Open. 2026.
Br J Anaesth. 2026.
This article presents a Delphi consensus developed by a panel of editors-in-chief of anaesthesiology and pain medicine journals to guide the responsible use of large language models (LLMs) in academic publishing. LLMs offer potential benefits for scientific writing, including language editing, summarisation, translation, information organisation, and support for non-native English speakers, but their misuse raises concerns about accuracy, transparency, confidentiality, and research integrity. Through a three-round modified Delphi process involving 53 editors-in-chief or their delegates, 59 statements were generated and categorised into guidance for authors, editors, reviewers, and publishers with a particular attention to LLM disclosure practices and perceived risks. The consensus recognises that LLMs are useful tools in academic publishing for authors, reviewers, and editors. However, their use must be guided by ethics, legality, and principles of transparency and accountability. LLMs may assist with limited editorial and authorial tasks provided that their use is fully disclosed and all outputs are verified by humans. The consensus also emphasises the inappropriateness of using LLMs to generate original or ideative content, which should remain a strictly human responsibility. Moreover, LLMs must not generate data, references, conclusions, or entire manuscripts, nor be used for editorial decisions or peer-review reports. Editors expressed concerns about 'hallucinations', erosion of critical skills, confidentiality breaches, and the proliferation of low-quality LLM-generated manuscripts. The resulting guidance highlights transparency, human accountability, and careful verification as essential principles for integrating LLMs into scholarly workflows while preserving the integrity of scientific publishing.
BMC Anesthesiol. 2026.
The American Society of Anaesthesiologists Physical Status (ASA-PS) classification system is the most widely used tool for estimating perioperative risk. Despite its widespread application, the ASA-PS is based solely on the subjective assessment of the patient’s clinical condition and comorbidities, which leads to considerable inter-rater variability. The aim of this study was to investigate interprofessional differences in ASA-PS scoring between surgeons and anaesthesiologists.
Anaesthesiologie. 2026.
Infection. 2026.
Sepsis is a leading cause of morbidity and mortality, yet its documentation and coding in administrative health data remain unreliable. Accurate coding is essential for epidemiological surveillance, quality assurance, and reimbursement. This study aims to identify patient characteristics associated with under-diagnosis and under-coding of sepsis in German inpatient administrative health data (IAHD).
Curr Opin Anaesthesiol. 2026.
The anaesthesia community should play a more active role in shaping sustainable healthcare practices. Current environmental measures, such as the European Commission's impending restriction on desflurane (an inhaled anaesthetic) from January 2026, risk unintended consequences for patient care and clinical autonomy.
Anaesthesiologie. 2026.
Anasthesiol Intensivmed Notfallmed Schmerzther. 2026.
In women of reproductive age, particularly during pregnancy and childbirth, patient blood management (PBM) plays an important role in reducing the risk of anemia and hemorrhage. These conditions are leading causes of maternal morbidity and mortality worldwide. By promoting early detection and treatment of iron deficiency anaemia, the implementation of a holistic PBM programme enables better outcomes for both, the mother and child. Implementing PBM protocols in perioperative care of women and perinatal care of parturients is essential to enhancing women's, maternal and neonatal health on a global scale.
Anasthesiol Intensivmed Notfallmed Schmerzther. 2026.
Gender specific differences are a current and increasingly discussed topic. Cardiovascular conditions in women are often diagnosed later and with more advanced severity. Similarly, women are frequently underrepresented in studies investigating the effects of anesthetics on the central nervous system. In the field of anesthesiology, scientific interest in this topic has grown rapidly. Gender specific differences arise from anatomical, physiological, and psychosocial factors, all of which can significantly influence the perioperative and postoperative management. This highlights the importance of awareness and appropriately addressing these differences. The aim of this review article is to summarize the most relevant sex-specific differences in the field of anesthesiology.
Anasthesiol Intensivmed Notfallmed Schmerzther. 2026.
J Cardiothorac Vasc Anesth. 2026.
To evaluate whether platelet function is preserved after intraoperative autotransfusion using the Same system, a device designed to retain both red blood cells and platelets in patients undergoing on-pump cardiac surgery.
JAMA. 2025.
Intraoperative hypotension is associated with organ injury. However, it remains unknown if targeted blood pressure management during surgery can improve clinical outcomes.
Lancet Glob Health. 2025.
Preoperative anaemia is a major risk factor for perioperative morbidity. Because iron deficiency is widely assumed to be the main cause of anaemia in surgical patients, treatment efforts have focused mostly on iron supplementation. However, the aetiology of anaemia is multifactorial. To further understand the underlying causes and consider a comprehensive approach to anaemia management, we studied the prevalence and aetiology of preoperative anaemia in patients undergoing major surgery.
J Cardiothorac Vasc Anesth. 2025.
To determine the incidence and subsequent complications of internal jugular vein (IJV) thrombosis after cannulation performed during cardiopulmonary bypass (CPB) to ensure adequate venous drainage during minimally invasive cardiac surgery.
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Universitätsklinikum
Frankfurt am Main
KAIS – Haus 13a
Theodor-Stern-Kai 7
60596 Frankfurt am Main
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